New York's offense was led by Super Bowl XLII winning quarterback Eli Manning, in his seventh season as the team's starter.
Manning set new career highs in nearly every statistical category in 2011, throwing for a franchise record 4,933 yards and 29 touchdowns, with 16 interceptions, giving him a 92.9 passer rating.
But the Giants prevented the Patriots from scoring again, and two consecutive New York field goals chipped away New England's lead, 17–15, late in the third quarter.
The Giants capped off an 88-yard drive with running back Ahmad Bradshaw's 6-yard game-winning touchdown with 57 seconds left in the game.
His top target was receiver Victor Cruz, who caught 82 passes for a franchise record 1,536 yards (3rd in the NFL) and 9 touchdowns.
But he had plenty of other targets, including Hakeem Nicks (76 receptions, 1,192 yards, 7 touchdowns), Mario Manningham (39 receptions and 523 yards in 12 games) and tight end Jake Ballard (38 receptions, 604 yards).
Pierre-Paul racked up 86 combined tackles and ranked fourth in the NFL with 16.5 sacks, earning him the only Pro Bowl selection on the Giants defense, while Umenyiora, limited to 9 games because of injury, recorded 9 sacks and 2 forced fumbles.
Super Bowl XLVI was the sixth Super Bowl in which the two teams had competed in a previous Super Bowl matchup, as the Giants and Patriots had previously met in Super Bowl XLII.
Eli Manning, who completed 30 of 40 passes for 296 yards, one touchdown, and no interceptions, was named Super Bowl MVP for the second time in his career.